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Diabetes Research

Type 2

Type 2 diabetes in individuals under the age of 18 is a recent development, its incidence is on the rise and First Nations people are disproportionately affected. Type 2 diabetes in youth is characterized by a much more rapid progression to hyperglycemia and an earlier onset of diabetes complications compared to adults.
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Early Life Origins of Diabetes

Environmental exposure in early life have long-term impacts on the risk for diabetes development.
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Pancreas Biology

Clusters of cells within the pancreas produce hormones such as insulin that control the levels of sugars in the bloodstream. Dysfunction in these cells leads to diabetes.
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Interventions

We collaborate to translate our research findings into novel interventions that improve the wellness of children and their families affected by diabetes. We invite you to learn more about our ongoing projects.
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Metabolism

The metabolic factors that contribute to type 2 diabetes development in youth may be different from those in adults. Through our interdisciplinary research we investigate how a wide range of metabolites and metabolic processes in a variety of organ systems.
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Epigenetics

Environment exposures can impact the way genes work. Our team is investigating epigenetics to understand the mechanism and timing of biological embedding of exposures on long-term healt.
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Complications

Diabetes can lead to a range of complications including atherosclerosis, high blood pressure, kidney disease and blindness. Bringing together interdisciplinary researchers, we are advancing the understanding of the complex interactions between type 2 diabetes in youth and its complications.

Clinical Studies in Type 2 Diabetes

CLIMB

A pilot open-label randomized controlled trial of the Medtronic 770g in automode vs manual mode in people with type 1 diabetes postpartum.

CONCEPTT Kids

Using individuals from the CONCEPTT study, CONCEPTT Kids is assessing the association between mother’s blood glucose during pregnancy on their child’s IQ, social responsiveness, attention and language scores. Recruitment is from CONCEPTT enrollment.

CIRCUIT

Aims to assess the efficacy of the Tandem t:slim X2 insulin pump with Control-IQ technology in pregnant individuals with type 1 diabetes.
Currently Recruiting

Basic Science Studies in Type 2 Diabetes

PREDISPOSE

Aims to predict the risk of developing type 2 diabetes after having gestational diabetes using continuous glucose monitoring technology.
Currently Recruiting
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Key Findings

All Articles
Featured image for “24-h ambulatory blood pressure readings and associations with albuminuria in youth with type 2 diabetes: A cross-sectional analysis from the iCARE cohort”
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24-h ambulatory blood pressure readings and associations with albuminuria in youth with type 2 diabetes: A cross-sectional analysis from the iCARE cohort

24-hour ambulatory blood pressure monitors (ABPMs) are recommended for screening at risk children, however this test is not often used…
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Featured image for “A new piece of the puzzle to explain how Type 1 Diabetes occurs and model the process in beta cells”
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A new piece of the puzzle to explain how Type 1 Diabetes occurs and model the process in beta cells

A new study by CHRIM staff member and lead author Gabriel Brawerman in the lab of Dr. Peter Thompson has…
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Featured image for “Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets”
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Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets

Dr. Doucette, Dr. Dolinsky, and Dr. Hatch conducted a study to study the role of TAZ (Tafazzin), a cardiolipin (CL)…
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