DREAM investigator Dr. Ayesha Saleem recently published two papers!
The first paper “Extracellular Vesicles Released From Skeletal Muscle Post-Chronic Contractile Activity Increase Mitochondrial Biogenesis in Recipient Myoblasts” was published on April 10, 2025 in the Journal of Extracellular Vesicles.
They show for the first time that skeletal muscle derived extracellular vesicles (EV) obtained from chronically contracted (exercised) cells, can be used to stimulate an increase in mitochondrial biogenesis in other muscle cells, likely through proteins associated with the EV membrane. It highlights a novel and exciting role of EVs in transmitting pro-metabolic effects. Many chronic conditions that affect children and adults have roots in metabolic insufficiency (e.g., mitochondrial disorders, type 2 diabetes, obesity, cancer, asthma etc.). Based on this work, harnessing the ‘exercise’-induced EVs to rescue metabolic dysfunction in these conditions is a viable and putative avenue of future research to explore.
Published in the Journal of Extracellular Vesicles, the top journal in the EV field, with an impact factor of 15.5 and a cite score of 27.3, considered to be excellent and highly respectable.
https://isevjournals.onlinelibrary.wiley.com/doi/full/10.1002/jev2.70045
The second journal publication, “Exercise-induced extracellular vesicles mediate apoptosis in human colon cancer cells in an exercise intensity-dependent manner” was published on April 20, 2025, in the European Journal of Applied Physiology.
This shows that exercise derived EVs from healthy human participants exerts anti-tumorigenic effects on human colon cancer cells in an exercise-dependent manner. It strengthens the role of exercise-EVs in transmitting the beneficial adaptations associated with regular physical activity.
Click here to read more of Dr. Saleem’s publications.
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